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Constipation and diarrhea can alternate as your gut adjusts to reduced food intake and medication effects

The rationale for blending these two peptides stems from their non-overlapping receptor targets and complementary metabolic effects: Amylin Pathway (Cagrilintide): Targets amylin receptors in the brainstem Creates meal-specific satiety signals Slows gastric emptying through distinct mechanisms Reduces meal size and eating frequency Triple Agonist Pathway (Retatrutide): Activates GIP, GLP-1, and glucagon receptors Enhances insulin secretion and glucose metabolism Increases energy expenditure through glucagon effects Provides broader metabolic regulation When combined, these pathways could theoretically provide additive or synergistic effects on weight management and metabolic function

First CV signal for semaglutide

I will probably only use this for another 2-3 weeks to drop another 7-10lbs

Effect of Obesogenic Medications on Weight-Loss Outcomes in a Behavioral Weight-Management Program: Obesogenic Drugs and a Weight-Loss Program