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Its only completed human trial (for post-operative ileus) did not meet its primary endpoint, and development was discontinued

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In humans, OCT1 is mainly expressed in the sinusoid membrane of hepatocytes, whereas in rodents, OCT1 is strongly expressed in the basolateral membrane of renal proximal tubule cells

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In particular, abundant evidence indicates metformin has significant anti-cancer activity

You are pregnant or breastfeeding : Berberine may worsen jaundice in infants or cause a more severe condition that can lead to brain disorders