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Available research lacks sufficient data to determine whether differences in CNS penetration between individual GLP-1 RAs are clinically meaningful

Saxenda, being an older GLP-1 medication, has some downsides compared to newer options like Zepbound

Gastrointestinal Issues: This can cause constipation and diarrhea, generally when the dose is increased

Druckers team, the mechanism of anti-inflammatory action of GLP-1RAs was explored, revealing a key role for the CNS in regulating this anti-inflammatory effect

Shawky E, Surendran S, El-Khair RMA (2025) Fermented vegetables as a source of psychobiotics: A review of the evidence for mental health benefits