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The pro-inflammatory triggers apparently increased TNF- and IL-6 release, while GHK-Cu apparently reduced both cytokines
X-ray crystallographic studies have demonstrated that copper coordination occurs through the N-terminal amino group of glycine, the deprotonated peptide nitrogen of the Gly-His bond, and the imidazole nitrogen of histidine, forming a square-planar geometry characteristic of Cu(II) complexes
The cDNA of 2.2 kb-fragment sequence codes for a 656 residue and 7077 kDa protein 13
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PMID 25826322
Lin W, et al
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