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Roche continued to rank #1 in oncology breadth in 2025, with multiple cancer blockbusters (Perjeta, Ocrevus, Tecentriq) each generating $510B+ annually, supported by companion diagnostics leadership
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Gln 24 Substituting GLP-1 Ala 30 with Gln decreases the affinity (IC 50 : 0.27 nM1.4 nM) but increases activity (EC 50 : 2.6 nM0.5 nM)
persistent severe symptoms may necessitate discontinuation
