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Downregulated in HCC 31,32,33 , HNF4 is considered as a tumor suppressor that represses the development of HCC and inhibit epithelial-mesenchymal transition (EMT), a process that promotes cancer progression and metastasis 34,35,36
bile acid receptor) in L cells have shown more promise in experimental systems [48], but the results have not yet been translated to humans
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J Innate Immun (2012) 4:44653
Metabolic conditions : Hyperparathyroidism, gout, inflammatory bowel disease, type 2 diabetes/metabolic syndrome (particularly for uric acid stones due to low urine pH), and certain genetic disorders affecting urinary chemistry increase susceptibility
however, treatment directed at increasing HDL-C levels has not proven to reduce the risk of ASCVD [10, 16]
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