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Some patients jump from 0.25 mg to 1.0 mg after just two weeks because they did not feel anything at the starting dose
When these receptors are blocked, the buzz or pleasurable feeling associated with substances (and sometimes food) is diminished
Weeks 9 through 12 at 8mg typically produces the most dramatic changes
Semaglutide discontinuation data from the STEP 1 extension study showed approximately two-thirds of lost weight was regained within one year of stopping treatment
Cell 61 , 705719 (2016)
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