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However, if accompanied by excessive thirst, frequent urination, confusion, abdominal pain, or difficulty breathing, immediate medical evaluation is necessary to rule out more serious metabolic disturbances

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10.1164/ajrccm.149.2.7508323

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This issue is particularly relevant in epithelial organs such as the kidney, where tubular cells are aligned along the nephron axis but are not necessarily in continuous plasma membrane contact

These example protocols illustrate how principles translate to actual practice