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As has been also found for other steroid hormone receptors such as estrogen receptors, androgen receptors can have actions that are independent of their interactions with DNA
For example, Kras G12D released from autophagy-dependent ferroptotic cancer cell death can limit the antitumour effects of macrophages by activating STAT3-mediated AGER-dependent M2 macrophage polarization [114]
It suggests that substantial therapeutic value may reside in revisiting known peptide systems with modern tools, rather than focusing exclusively on the discovery of entirely new ligands
As a reference, recombinant IGF-1 injections have a half-life of under 6 hours when given subcutaneously as a treatment of growth failure and slower development of children due to poor IGF-1 levels
PDI 0.084 confirms uniformity
