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Gen Comp Endocrinol
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The first reaction is catalyzed by tryptophan hydroxylase (TPH-1), which requires L-tryptophan, tetrahydrobiopterin (BH4), and O 2 as co-substrates, and has ferrous ion (Fe 2+ ) as an activator
However, because of the structural differences among different therapeutic GLP-1RAs, there is also a significant distinction in their stability, which affects their administration schedule, and thus they are often classified as either short- or long-acting
& Boekelheide, K
