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The gallbladder empties less frequently during weight loss, which makes bile more concentrated and increases the risk of gallbladder issues
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Combined with appetite suppression and increased metabolic output, retatrutide triggers deeper fat-cell depletion than single-agonist therapies
However, compared to endoscopic sleeve gastroplasty, semaglutide is less cost-effective over 5 years with the same outcome parameters and a current annual price of approximately $13,618 in the US [144, 145]
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