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6.1 Insulin therapy Absolute insulin deficiency is the main characteristic of PDM that makes insulin replacement the foundation of its treatment ( 6.1.1 Principles of insulin therapy The most flexible option from a physiological point of view is the basal-bolus regimen, which comprises basal insulins of long-acting formulations such as glargine and degludec, and rapid-acting insulins at meal-time

GLP-1 receptor agonists have gained attention primarily for weight loss, yet mounting clinical evidence indicates they may also address systemic inflammationa silent driver of cardiovascular disease, type 2 diabetes, and metabolic dysfunction

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Proper medical oversight during administration minimizes these risks