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The compound that made ghrelins discovery possible remains the right tool when the question extends beyond the pituitary

Key properties: Strong appetite stimulation the most pronounced of any GHRP (can be a benefit or drawback) Moderate cortisol increase higher than GHRP-2 Good GH release effective but not as potent per mcg as GHRP-2 Strongest ghrelin mimicry most activation of non-GH ghrelin pathways GHRP-6 is studied when appetite stimulation is a desired effect (e.g., recovery from illness, muscle gain phases) alongside GH release

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Chronic conditions respond less predictably