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The H 2 O 2 concentration drives the redox balance in the cell from GSH toward GSSG (see Figure 1) and the increased concentrations of H 2 O 2 and GSSG can modulate many enzymes in one-carbon metabolism (see Section E)
Ocampo A et al
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The prodrug is rapidly internalized by phagocytic synovial cells and processed intracellular to release free Dex, leading to sustained improvements in joint inflammation and pain in models of arthritis
This ensures adherence to regulatory standards for clinical safety and hygiene
It accelerates degradation
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