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GHK-Cu delivers bioavailable copper directly to fibroblasts, supporting this enzymatic step

P-value histogram from t-tests between uterine vein and radial artery (maternal side of the placenta) showing an overabundance of very low p -values along with a uniform distribution of higher p -values, indicating that statistical testing assumptions are met, experimental bias is minimal and that we can expect true positive results

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As illustrated in Scheme 1B, once the GCMMR NPs were endocytosed by cancer cells through the RGD-mediated targeting affinity, the outer PEG was destroyed in the acidic TME, following which MNSs converted GSH into glutathione disulfide (GSSG) and released MET to alleviate the hypoxia of TME as well as interfere with energy supply by inhibiting mitochondria-mediated respiration