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the progressive deposition of extracellular matrix proteins, including FN, LN, and collagen proteins, is induced, leading to metabolic abnormalities in mesangial cells ( The Nrf2/HO-1 pathway plays a role in modulating inflammatory reactions through diverse signaling pathways

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They disrupt fundamental cellular processes, including energy production, insulin signaling, glucose metabolism, and mitochondrial function, at times contributing to cognitive decline, fatigue, reduced ability to fight infections, and increased chronic disease risk

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