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Heart failure Analysis of myocardial samples from patients with ischemic and dilated cardiomyopathy in the terminal stage of heart failure, as well as from heart donors without heart disease, found that the downregulation of multiple mitochondrial quality control genes, including LONP1, is closely related to heart failure [63]

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2.8 Immunohistochemicalimage analysis for CD68 Quantitative immunohistochemical analyses of CD68 expressions in all the examined renal tissues were scored using the Leica Qwin 500 Image Analyzer (Leica Imaging Systems Ltd., Cambridge, London) in the Pathology Department of Cairo Universitys Faculty of Veterinary Medicine as outlined by Smolen (1990), where the brown color intensities were expressed as the relative optical density of the DAB reaction

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