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Lilly's Oral GLP-1, Orforglipron, Demonstrated Meaningful Weight Loss and Cardiometabolic Improvements in Complete ATTAIN-1 Results Published in The New England Journal of Medicine
Sci Rep 9, 14754 (2019)
Abdominal (visceral) fat is a particularly dangerous part of menopause weight gain because it releases pro-inflammatory cytokines that promote insulin resistance, the primary contributor to type 2 diabetes
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GLP-1s for Cyclists: Miracle Weight Loss or Performance Sabotage
The increased presence of FFAs in the liver activates tumor necrosis factor- (TNF-) production in hepatocytes, which in turn inhibits hepatic adiponectin activity and promotes both MASLD and hepatic IR [51]
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