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The same 2g administered intravenously or via intramuscular/subcutaneous injection delivers close to 100% systemically At 500mg/ml, a single 2ml injection of Dragon Pharma L-Carnitine delivers 1,000mg with near-complete bioavailability equivalent to approximately 5,500-7,000mg of oral L-Carnitine supplement in terms of what reaches the bloodstream This bioavailability advantage is particularly relevant for the androgen receptor upregulation application (below), where plasma L-Carnitine concentrations not gut absorption determine the effect How L-Carnitine Works The CPT Shuttle Mechanism L-Carnitine's primary metabolic function is a specific and elegant transport mechanism that most competitor content reduces to "moves fat to mitochondria": Long-chain fatty acids (the primary fat fuel for aerobic metabolism) cannot cross the inner mitochondrial membrane directly they require a specific transport system L-Carnitine acts as the shuttle carrier in the carnitine palmitoyltransferase (CPT) system : CPT1 on the outer mitochondrial membrane conjugates L-Carnitine to the fatty acid (forming acylcarnitine)

47 : 235248 Pettegrew JW, Panchalingam K, Klunk WE, McClure RJ, Muenz LR

Chen, T.-H

DENNING: So you design these trials, you spend maybe six months doing that, you start them up, and then you run the trial

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