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Weight regain upon discontinuation represents another substantial unmet need
The STEP 1 clinical trial, which investigated the efficacy of 2.4 mg semaglutide, included a substudy specifically analyzing body composition via dual-energy X-ray absorptiometry (DEXA) [1]
Our investigation has several strengths
Using human preterm intestinal organoids, we demonstrated that CFTR-dependent cell proliferation may be unique to the human premature intestine
Christ et al., 2013
Whether liver-specific GSH synthesis was responsible for downregulated lipogenic gene expression and reduced serum triglycerides or whether these phenotypes were a byproduct of a liver-independent process in Gclc KO mice was unclear
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