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Have sluggish thyroid function but are not candidates for thyroid hormone therapy
Tirzepatide provides a well-characterized, extensively documented platform for studying dual incretin agonism
It can be legally purchased for research purposes, and physicians may prescribe it for off-label use, often sourced from a compounding pharmacy that specializes in sterile peptide synthesis
However, such combinations require careful oversight and individualized planning
Their combined effects in humans are not well studied, and use outside regulated research is not recommended
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