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NPR reported that FDA scientists spoke extensively about the lack of reliable data for any of the seven peptides and that in some cases they could not find any published human clinical studies at all

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When vitamin B12 is supplemented and the skin appearance deteriorates, the folic acid and biotin status in the blood should also be measured

However, the review emphasized that the majority of studies utilized small rodent models, and efficacy in humans remains to be confirmed through adequately powered clinical trials

The rodent data are important background, but they represent the beginning of an evidence chain, not the end of one