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The Proteolytic Stability Engineering Semax's design addresses the rapid degradation that limits native ACTH(4-10), extending functional duration without fundamentally changing the plasma half-life
This, often absent in capillaries, is called the Virchow-Robin perivascular space, and it is filled with interstitial fluid that has lymphatic functions (Esiri and Gay, 1990)
10.1002/jcsm.13213 12 DongL.XieJ.WangY.JiangH.ChenK.LiD.et al (2022)
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