The rare individual who might consider this combination needs exceptional GI tolerance proven on prior GLP-1s, physician supervision with frequent monitoring, ability to afford $15,000-30,000 annually, understanding they're experimenting on themselves, and willingness to stop immediately if severe side effects emerge
Novo Nordisk received a similar letter over the same Oprah broadcast, with the agency saying the program presented Wegovy and Ozempics benefits while minimizing their risks
The rationale for stacking GHK-Cu vs NAD+ together is additive rather than synergistic: GHK-Cu handles structural repair while NAD+ handles bioenergetics
Like most things in nutrition and healthcare, its nuanced and my perspective has evolved as these medications have become more widely used
But of course, every drug, and especially every blockbuster drug, comes with major questions, such as why do GLP-1s seem to have an impact on such a wide range of ailments
Sonne DP, Engstrom T, Treiman M: Protective effects of GLP-1 analogues exendin-4 and GLP-1(936) amide against ischemia-reperfusion injury in rat heart