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& Santana, M

July 3, 2023

2 Wegovy 2.4 mg significantly reduced the risk for first occurrence of a three-part composite MACE endpoint consisting of cardiovascular death, non-fatal heart attack, or non-fatal stroke

Weeks 912 (if necessary): The dose may be raised to 1 mg once weekly if additional glycemic control is needed

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In the hypothalamus, liraglutide directly accessed the proopiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neurons expressing the GLP-1R, and appeared to be internalized, as expected when a GPCR ligand activates its receptor (117)