Weight loss and caloric restriction increase muscle proteolysis, providing amino acids for gluconeogenesis and acute-phase protein synthesis
Works by activating GLP-1 (glucagon-like peptide-1) receptors found in the pancreas, brain, and gastrointestinal tract
10.1371/journal.pone.0139593 6 ChenhuichenC.Cabello-OlmoM.BarajasM.IzquierdoM.Ramirez-VelezR.Zambom-FerraresiF.et al (2022)
It falls under S2: Peptide Hormones, Growth Factors, and Related Substances , alongside GH, GHRPs, and IGF-1 analogs
Kleinridders A, Ferris HA, Cai W, Kahn CR
Weight circumference in the semaglutide group was -13.4cm, compared with -2.4cm in placebo