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Accelerated tissue repair and reduced inflammation can support faster return to function after orthopedic procedures

Routes of Administration Subcutaneous injection is the standard route

However, the underlying mechanism by which MTX provokes tissue injury is not yet well known, and direct toxic effects of MTX are thought to be caused by excessive generation of free radicals, causing an imbalance between free radical production and antioxidant defense, which finally results in the development of oxidative stress (Drishya et al

Chen TS et al

PPARs and metabolic disorders associated with challenged adipose tissue plasticity

doi: 10.1093/jac/dky455 418 Trevio-RangelR