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178,179,180,181,182 Given that DNA damage-activated PARPs account for up to 90% of cellular NAD + consumption, the DNA repair activity is highly dependent on the cellular NAD + concentration
This regulation occurs at multiple levels: Genetic Regulation : Genes encoding the enzymes of the carnitine biosynthetic pathway are subject to transcriptional regulation by factors responsive to metabolic needs
Effect and distribution of vitamin BT
doi:10.2337/db15-0443 26
Lian Z, Wang X, Guo Y, et al
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