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Activation of the innate immune system attracts neutrophils and monocyte-derived macrophages (MoMFs) to locate in the inflammatory site [49, 50]

Moreover, other histidine residues of the neighboring PrPs can be involved in Cu 2+ anchoring, with an end result of PrP formation of oligomers (Yang et al., 2008)

Patients received standard therapy with a GH dose identical to each subject's prestudy therapy, with median 33 (range 1346) mcg/kg/d

Its mechanisms include the induction of OS and modulation of signaling pathways, which may also be relevant in neuropathic pain management (Lee et al., 2021)