Other significant considerations include: Injection site reactions (for subcutaneous formulations) Hypoglycaemia risk (particularly if used alongside other glucose-lowering medications) Pancreatitis (rare but serious) Gallbladder disease (including gallstones and cholecystitis) Dehydration leading to acute kidney injury (particularly with severe gastrointestinal side effects) Diabetic retinopathy complications (particularly noted with semaglutide in diabetes patients) Potential thyroid effects (medullary thyroid carcinoma risk in animal studies, though human relevance remains unclear) A Parkinson's-specific concern is that GLP-1 receptor agonists delay gastric emptying, which may further impair levodopa absorption and potentially worsen motor fluctuations or 'OFF' periods in patients on this medication
October 2025: More research shows that Zepbound and other GLP-1s raise the chances of someone experiencing blindness and other vision complications
GLP-1 agonist weight loss medications like Wegovy and Saxenda have a high probability of causing thyroid cancer based on available evidence These medications were originally designed for diabetes and then repurposed for weight loss, which means the long-term thyroid safety data is still limited The potential benefits of GLP-1 agonists for weight loss must be carefully weighed against the significant risk of developing thyroid cancer If you're considering these medications, have a detailed conversation with your doctor about your personal thyroid cancer risk versus the weight loss benefits Do the most popular weight loss medications of our time like Wegovy and Saxenda cause thyroid cancer
Sublingual Tirzepatide at UCP- is good choice for patients who dont want a shot
How PlexusDx Supports a More Personalized Approach PlexusDx's approach to compounded medication management integrates biomarker and genetic context with practical safety protocols
Furthermore, the company was cited for failing to establish and maintain procedures to ensure that the products and services it purchases meet the required specifications