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One-week treatment of DIO mice with G49 induces a transient lipid overload in the liver, increases ketogenesis and FGF21 levels Due to the rapid increase (16 h) in circulating FFAs in G49-treated mice (Fig
Separate trials have also explored its use specifically in people with type 2 diabetes
Glucagon-Like Peptide-1 Activates Endothelial Nitric Oxide Synthase in Human Umbilical Vein Endothelial Cells
Values summarised from cited preclinical studies (see references below)
Current Pharmaceutical Design, 26(29), 35383554
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