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PMID: 20524875 [LoE A] [2] Weschawalit, S., Thongthip, S., Phutrakool, P., & Asawanonda, P
The mechanism underlying L-Carnitine's anti-obesity effects involves multiple pathways: facilitating long-chain fatty acid entry into mitochondria for oxidation, preventing accumulation of toxic lipid intermediates that impair insulin signaling, enhancing mitochondrial bioenergetics to support greater metabolic capacity, and modulating inflammatory pathways that contribute to metabolic dysfunction
Cells were incubated in a humidity-controlled incubator at 37 C with 5% CO 2
doi: 10.3389/fphar.2025.1618079 Received 28 April 2025 Accepted 08 July 2025 Published 24 July 2025 Volume 16 - 2025 Edited by Karuna Rasineni, University of Nebraska Medical Center, United States Reviewed by Yang Yang, Chinese PLA General Hospital, China Asher Rajkumar Rajan, University of Nebraska Medical Center, United States Updates Copyright 2025 Xie, Yang, Tian and Chen
Other supplements shown to support the methylation process include choline and the B vitamins, especially folate and vitamin B12
Systemic side effects may occur in some individuals
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