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For example, the ingestion of trimethylamine-containing (TMA-containing) dietary nutrients enriched in animal products such as choline, phosphatidylcholine, and l-carnitine can serve as precursor for the ultimate generation of an atherogenic metabolite, trimethylamine N -oxide (TMAO), via a metaorganismal pathway involving initial gut microbial formation of TMA, followed by host hepatic conversion of TMA into TMAO (48)
However, chemotherapy efficacy is not expected due to its short blood circulation times, nonspecific cell and tissue biodistribution, and rapid metabolism or excretion from the body (Lyu et al
Their effects on the individual components of MACE, myocardial infarction (reduced in LEADER and Harmony Outcomes), and stroke (reduced in SUSTAIN-6 and REWIND), varied in each trial (Table 1)
Toxicol Pathol 30:524533
San taka vi hefbundnar jgafingar og vi endum 20 mn leiddri slkun
Delaying care will only worsen the symptoms
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