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Research progress on the GIP/GLP-1 receptor coagonist tirzepatide, a rising star in type 2 diabetes

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Diabetes 61, 187196

Mutations in the SLC22A12 gene can reduce SUA levels ( SLC22A12 was 10% more prominent in men than in women, and can be genetic ( ABCG2 The ATP binding cassette subfamily member 2 (ABCG2), a multi-specific transporter, is located on the apical membrane in tissues including kidney and intestine

Our results are clinically relevant and consistent with clinical reports that the secretory capacity of -cell was diminished in first-degree relatives of individuals with T2DM even before the onset of obesity and insulin resistance 32