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Some patients experience mild fatigue during the first week of treatment, which may represent the body's healing response rather than a true side effect

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This is especially the case after the loading period is finished, to help determine the right frequency thereafter

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All three NOS enzymes function as homodimers and the interactions of the subunits is required for the process of electron flow from NADPH (bound in the reductase domain of the enzyme), through the various co-factors to the heme moiety which is bound to the N-terminal oxygenase domain of the enzyme