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Time- and dose-related improvements in insulin sensitivity were similar to the temporal patterns of body weight loss with retatrutide in both the MASLD cohort reported here and in the full cohort of people with obesity 13

However, we can speculate that this may be caused by the onset of telogen effluvium

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They found that people taking Contrave lost around 6% of their body weight after 56 weeks

Bettini S, Bordigato E, Fabris R, Serra R, Dal Pra C, Belligoli A, et al