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Only about 1% of oral B12 is absorbed passively when intrinsic factor is absent or impaired

The Importance of FIH Trials in Clinical Development First-in-Human trials provide the first opportunity to translate preclinical evidence into early clinical knowledge

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While some of the trials reported a decrease in appetite as a side effect, like the ADJUNCT trials (60), it should be noted that this is one of the main mechanisms of action of these drugs to achieve weight loss