It is very nuanced for the individual, but I do think it's a really good idea that we are measuring serum estradiol
Enteric Nervous System (ENS) Signaling Analysis of cagrilintides influence on gut-brain communication and visceral sensitivity in gastrointestinal diseases
Oct 2010;25 Suppl 1:35-41
The best delivery method depends on your goals: For systemic benefits (anti-inflammation, cognitive support, immune modulation, energy, tissue repair throughout the body): Subcutaneous injection is the clear choice
DSIP is found in both free and protein-bound forms in the hypothalamus, limbic system, and pituitary gland, as well as in peripheral organs including the gut secretory cells, pancreas (where it co-localises with glucagon), and plasma with brain and plasma DSIP concentrations showing a marked diurnal variation that correlates with circadian rhythm in humans, with levels lowest in the morning and higher in the afternoon
Patients with the condition begin to experience hyperphagia and obesity in early childhood, along with reduced physical activity