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We can more easily show the impact of using a patent thicket strategy, where a drug manufacturer abuses the patent system through excessive and overlapping patents to increase the exclusivity period for their drug

This article examines the evidence, risk factors, and practical management strategies

[8] [10] Berberine's side effects are generally considered mild but can include gastrointestinal disturbances such as diarrhoea, constipation, abdominal pain, and nausea, particularly at higher doses

Some patients are also able to succeed at lower doses, which may reduce side effects while still delivering meaningful results

Since they do not require FDA approvals, compounded variants bypass premarket efficacy and safety reviews

But even with this limited use, their impact will be significant