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doi: 10.3389/fnut.2025.1598588 Received 23 March 2025 Accepted 08 May 2025 Published 30 May 2025 Volume 12 - 2025 Edited by Jing Gao, National Engineering Research Center for Oil Tea, China Reviewed by Tarique Hussain, Nuclear Institute for Agriculture and Biology, Pakistan Guiping Guan, Hunan Agricultural University, China Updates Copyright 2025 Li, Li and Fan

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In vitro studies reveal that kisspeptin enhances osteoblast activity, leading to a 41% increase in alkaline phosphatase levels, while simultaneously reducing osteoclast resorptive activity by 53%

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However, results from recent human studies have questioned the pharmacological relevance of 5-LOX inhibition by 11-keto boswellic acids (KBA and AKBA), since neither any boswellic acid nor Boswellia extract caused significant inhibition of 5-LOX in a physiologically relevant assay (human whole-blood assay), and oral intake of Boswellia extract failed to reduce leukotriene-B 4 (LTB 4 ) levels in human test subjects

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In rat pituitary cell cultures, CJC-1295 No DAC demonstrated 49-fold greater potency than native GHRH, representing the most potent GHRH analog in in vitro systems at the time of its characterization

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