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Because Accutane decreases sebum production, which can lead to dryness, the most common side effects include: Dry skin Dry mouth Chapped lips Nosebleeds (resulting from dry nasal passages) Dry eyes (especially in contact lens wearers) Other common side effects of Isotretinoin use include joint pain, muscle pain or aches, temporary hair thinning, skin irritation, and headaches

E., Ochocki, J

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Selected recent literature for research reference: Dehghanipour M et al