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The semaglutide component follows the same dose escalation schedule as standard compounded semaglutide: Weeks 1-4: 0.25 mg semaglutide (0.1 mL) Weeks 5-8: 0.5 mg semaglutide (0.2 mL) Weeks 9-12: 1.0 mg semaglutide (0.4 mL) Weeks 13-16: 1.7 mg semaglutide (0.68 mL) Week 17+: 2.4 mg semaglutide (0.96 mL) The niacinamide dose scales proportionally with the injection volume
We also know that certain populations pregnant or breastfeeding women and people with a history of cancer are contraindicated for peptide use
Semaglutide Dosing Schedule and Weight Loss Outcomes Clinical evidence from the STEP trials showed that participants receiving 2.4 mg of semaglutide weekly lost an average of 15% of their body weight over 68 weeks, compared to less than 3% in the placebo group
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