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62 Collectively, the evidence supports a mechanism-informed, risk-stratified clinical approach that prioritises gradual dose escalation, anticipatory counselling, functional monitoring, and targeted vigilance in susceptible subgroups, while recognising persistent evidence gaps and the need for long-term, high-quality, real-world safety data to characterise uncommon and delayed adverse outcomes associated with GLP-1 receptor agonists
In research settings, it has been observed to increase pigmentation and modulate central pathways influencing libido and appetite
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Unlike earlier GH secretagogues, ipamorelin exhibits high selectivity, minimal activity at other hormonal axes (ACTH, cortisol, or prolactin), and potent GH release in both animals and humans
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