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Estrogen-driven collagen decline accelerates during perimenopause, and substrate is typically already more depleted at baseline

Deficiency is widespread, with peer-reviewed research describing it as a global health concern affecting populations across all age groups and geographies (Cashman et al., American Journal of Clinical Nutrition , 2016

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its proposed activity is linked to the copper it delivers

The honest caveat: most of this evidence is from cell and animal studies

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