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GH acts on target tissues mainly via stimulation of the somatomedin insulin-like growth factor-1 (IGF-1, 7.6 kDa), and to a lesser extent, directly in an IGF-1 independent manner

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This albumin-binding property extends the half-life of CJC-1295 to several days, creating a more sustained elevation in baseline GHRH receptor stimulation compared to shorter-acting analogs like MOD GRF 1-29