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12 The substitution of GLP-1 Thr 13 or GIP Ile 7 with Ala obviously decreased their receptor-activating activities 25,26 and the substitution of GIP Ile 7 with Thr decreased its cAMP activity (pEC 50 : 9.769.58;Emax: 9.918.90)

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According to a recently published studies, GLP-1RAs reduce glycated hemoglobin (HbA1c) levels and body mass index in patients with T2DM, as well as the risk of developing AD and related dementias by 26% [38, 39]

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