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In a randomized, double-blind, placebo-controlled trial, once-weekly exenatide (2 mg) administered for 48 weeks significantly improved motor scores in patients with PD, with benefits sustained even after treatment discontinuation ( Collectively, these findings indicate that incretin mimetics provide neuroprotection extending beyond metabolic regulation by targeting multiple pathogenic processes in PD, including mitochondrial dysfunction, neuroinflammation from oxidative stress, sirtuin dysregulation, insulin resistance, and S toxicity (Figure 2)

GLP-1 can result in considerable weight reduction, with individuals experiencing an average loss of 10-20% of their total body weight

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Treatment with 0.1% Camellia japonica extract led to notable enhancements in the clinical manifestations of dry eye, including increased tear production and diminished inflammation, with a substantial reduction in inflammatory marker levels [74]