Mild temporary tenderness, a small bruise, or limited redness can sometimes occur
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4 Clinical Effects in Humans 4.1 Peripheral Effects In 1998, Flint et al
For best results, use the cream twice daily, morning and night
No peer-reviewed randomised controlled trials have validated berberine patch efficacy or systemic absorption
doi:10.2174/1381612824666180712110447 Gwyer D, Wragg NM, Wilson SL