Potential Benefits Beyond Weight Loss While its impact on fat metabolism is what initially draws attention, the influence of 5-Amino-1MQ extends far beyond the scale
AOD 9604 is an investigational compound, which means appropriate use is determined by a licensed medical provider, not copied from a blog
NNMT (nicotinamide N-methyltransferase) is the enzyme 5-Amino-1MQ inhibits, and tissue expression varies significantly across organs: adipose tissue shows 812 higher NNMT activity than skeletal muscle, which is why subcutaneous injection near adipose depots produces localised effects rodent models couldn't predict
Small molecule inhibitors of nicotinamide N-methyltransferase (NNMT). Journal of Medicinal Chemistry, 59(19), 90399056
It was designed by Eli Lilly and first described in 2022 in Cell Metabolism
Importantly, there was an apparent improvement in cardiac function in the cAtg3-KO mice following treatment [8]