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A.BhatR
Structural Significance of Non-Proteinogenic Residues: Aib (N-terminal position):Reduces conformational flexibility of the peptide backbone, locking it into a bioactive conformation and enhancing its stability against enzymatic degradation D-2-Naphthylalanine (position 3):Provides hydrophobic interactions with the GHSR-1a receptor binding pocket while conferring resistance to peptidase cleavage
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Somatostatin restrains the secretion of glucagon-like peptide-1 and -2 from isolated perfused porcine ileum
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the glucagon arm additionally nudges energy expenditure and hepatic fat handling upward
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